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specific polypeptide producing hybridzellinien, available from primaerzellen who spontaneously to expres sion of this polypeptids are able or a similar polypeptids, procedures to receive these hybrid cells and their use for the production of this polypeptids.
specific polypeptide producing hybridzellinien, available from primaerzellen who spontaneously to expres sion of this polypeptids are able or a similar polypeptids, procedures to receive these hybrid cells and their use for the production of this polypeptids.
Hybrid cells transformed or transformable by a cloned DNA sequence containing the sequence coding for a determined polypeptide, for example an immunogene polypeptide having vaccination properties to hepatitis B. They are characterized in that they contain on one hand at least a portion of the genotype of a primary cell lineage which are naturally favorable to the expression of said DNA sequence and on the other hand a genetic marker which enable them to grow in a selective medium or containing an active principle which is normally lethal for the cells from which the hybrid is issued, but unactivable by the polypeptide expressed by said genetic marker.
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