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depolymerisierte hexosaminoglykansulfate with antithrombogener, fibrinolytischer and entzuendungshemmender aktivitaet, procedures for their production, and related compositions.
depolymerisierte hexosaminoglykansulfate with antithrombogener, fibrinolytischer and entzuendungshemmender aktivitaet, procedures for their production, and related compositions.
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机译:用抗血栓形成剂,纤维蛋白溶解剂和抗炎活性剂解聚己糖氨基甘氨酸硫酸盐,其生产程序及相关组成。
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摘要
Process for the preparation of oligosaccharides by a controlled chemical depolymerization of natural polysaccharides, such as heparins, heparan sulfates, dermatan sulfates, chondroitinsulfates, hyaluronic acid, by a radicalic reaction in an aqueous solution, at a temperature ranging between 20 DEG and 70 DEG C., in the presence of a catalyst selected in the group consisting of Cu++, Fe++, Cr+++, Cr2O7- as well as the resulting oligosaccharides and their related pharmaceutical compositions. The products exhibit high antithrombotic activity, little or no anticoagulant activity, high fibinolytic activity an antiinflammatory activity.
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