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Phenyl hydroxamic acids comprising a substituent heteroatomic, a force application no.
Phenyl hydroxamic acids comprising a substituent heteroatomic, a force application no.
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机译:包含杂原子取代基的苯基异羟肟酸,强制申请No.
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摘要
Phenyl hydroxamic acids having the formula:- IMAGE or a pharmaceutically acceptable salt thereof, wherein X is HR, oxygen, sulfur, IMAGE or a single bond, and Y is NR, oxygen, sulfur, IMAGE or a single bond, where R can be hydrogen or lower alkyl, g can be 1 or 2, and with the proviso that at least one of X and Y is other than a single bond; Z is aryl, aralkyl or cycloalkyl; R1 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl or aryl; R2 is hydrogen, lower alkyl, aroyl or acyl; m is 0 to 4 can atoms; and, n is 0 to 4 carbon atoms, are inhibitors of arachidonic acid 5-lipoxygenase and are therefore useful as antiallergy agents and antipsoriatics.
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机译:具有下式的苯基异羟肟酸或其药学上可接受的盐,其中X为HR,氧,硫,或单键,Y为NR,氧,硫,或单键键,其中R可以是氢或低级烷基,g可以是1或2,条件是X和Y中的至少一个不是单键; Z为芳基,芳烷基或环烷基; R1是氢,取代或未取代的低级烷基,环烷基,低级烯基或芳基; R 2是氢,低级烷基,芳酰基或酰基; m为0至4个罐原子; n为0至4个碳原子,是花生四烯酸5-脂氧合酶的抑制剂,因此可用作抗过敏剂和抗银屑病药。
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