INCLUSION COMPOUND OF ALPHA-CYCLODETRIN AND SEPARATION AND PURIFICATION OF ALPHA-CYCLODEXTRIN

摘要

PURPOSE:To provide the subject inclusion compound composed of alpha-cyclodextrin molecule constituting an inclusion lattice and a polyethylene glycol molecule included therein and useful for separation and purification of high-purity alpha- cyclodextrin suitable, e.g. for supporting and stabilizing medicines. CONSTITUTION:A mixture of various cyclodextrins containing alpha-cyclodextrin is mixed with a polyethylene glycol having 400-50000 molecular weight in the presence of water to produce an insoluble alpha-cyclodextrin inclusion compound composed of alpha-cyclodextrin molecule constituting an inclusion lattice and a polyethylene glycol molecule included therein. An organic solvent is then added to the resultant alpha-cyclodextrin inclusion compound to remove the polyethylene glycol from the alphaRHO.