CYANATION OF HALOAROMATIC COMPOUND BY USING CATALYST PREPARED IN SITU FROM NICL2 OR NICL2.6H2O

摘要

PURPOSE: To obtain an-aromatic nitrile, which is useful as an intermediate for producing medicines and agricultural chemicals, at a reduced catalyst cost with a high yield by the cyanation of a haloaromatic compound using a catalyst prepared in situ, using nickel chloride as the starting material. ;CONSTITUTION: Ni(Pϕ₃)₂Cl₂ catalyst is obtained by reacting NiCl₃ or NiCl₃.6H₂O and Pϕ₃ (ϕ is phenyl) as the starting material so as to produce substantially dry Ni(Pϕ₃)₂Cl₂, and reacting the Ni(Pϕ₃)₂Cl₂ with at least one equivalent Pϕ₃ in a reaction solvent selected from the group consisting of a 2-5C alcohol (t- butanol is particularly preferable) and an aprotic polar solvent (acetonitrile is particularly preferable) in the presence of a reducing metal having a reducing potential larger than Ni in the same reaction vessel as the above reaction. Then, an aromatic nitrile can be obtained by adding a compound represented by the formula (wherein X denotes Cl or Br; Y denotes CHO or CF₃; (m) is 1 to 3; and (n) is 0 to 2) to the above reaction vessel so as to form a complex with the catalyst, and adding NaCN or KCN.;COPYRIGHT: (C)1990,JPO