SUPPORT FOR IMMOBILIZING PHYSIOLOGICALLY ACTIVE SUBSTANCE AND SELECTIVE ADSORBENT

摘要

PURPOSE:A support for immobilizing a physiologically active substance free from nonspecific adsorption of proteins, and an adsorbent which is made by immobilizing a physiologically active substance on the support surface, thus showing specific adsorption. CONSTITUTION:The particles of hydrophobic organic synthetic high molecular weight polymer which is impermeable to liquid and nonswelling with the liquid and has reactive groups such as epoxy or aziridyl groups on their surfaces are coated with a hydrophilic high molecular weight polymer containing about 50- 99wt% of the units of formula I and about 1-50wt% of at least one selected from units of formula II, III and IV and crosslinked with covalent bonds between the reactive groups of the hydrophilic polymer and the reactive groups on the particle surfaces to produce the objective support free from peeling of the polymer coating. Then, antigen, antibody, complement, receptor, enzyme or other physiologically active substance is immobilized through the carboxyl or amino groups on the hydrophilic surface of the support by the direct or indirect method.