A process for preparing 1,1-DIOXOPENICILLANOYLOXYMETHYL-6- (2-amino-2-phenylacetamido) penicillanate 1,1-OR-6-DIOXOPENICILLANOYLOXYMETHYL OE2-amino-2- (p-hydroxyphenyl) ACETAMIDOAAPENICILLANAT or pharmaceutically acceptable acid addition salts thereof, and DIHALOGENSUBSTITUEREDE Derivatives of these compounds for use as starting material in the method

摘要

Compounds of the formula CHEM wherein R1 is H or HO; Y and Z are each Cl, Br or I, or Y is H and Z is Cl, Br or I; Q is N3 or NHCO2CH2C6H4R4 where R4 is H, Cl, Br, NO2, CH3 or OCH3; a process for their use in production of the valuable antibacterial agents 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanate and 1,1-dioxopenicillanoyloxymethyl 6-[2-amino-2-(p-hydroxyphenyl)acetamido]penicillanate, by catalytic hydrogenation in the presence of a noble metal catalyst and novel intermediates useful in preparing said compounds of formula (I).