FRAMEWORK FOR THE FRAMEWORK OF THERAPEUTIC ANALYZES

摘要

Phenoxy-substituted beta-carbolines of the formula I IMAGE (I) X is COOR3, CONHC1-3-alkyl or oxadiazolyl of the formula IMAGE R2 is H, lower alkyl or cycloalkyl, R3 is lower alkyl, R4 is hydrogen, lower alkyl or lower alkoxyalkyl, R1 is hydrogen, halogen, lower alkyl, lower alkoxy, acyl, phenyl, C2-5 alkylenedioxy, trifluoromethyl, nitrilo, nitro, lower alkoxycarbonyl, azido, SO2R6, SO2NR7R8, or NR9R10, R6 is lower alkyl, R7 and R8 independently are lower alkyl or together with the nitrogen atom form a hetero ring, R9 and R10 independently are hydrogen, lower alkyl, acyl or together with the nitrogen atom form a hetero ring system, with the proviso that X is not COOEt, if IMAGE (a) is 5-phenoxy and R4 is methyl or IMAGE (b) is 6-(4-methoxyphenoxy) and R4 is methoxymethyl have valuable pharmacological properties.