Process for the preparation of phenylacetic derivatives of thienopyridines and of the intermediate Ó-bromo-phenylacetic acids

摘要

Compounds of formula IMAGE I in which R1 and R2 are hydrogen or halogen, are prepared by reacting an aldehyde of formula: IMAGE IV with CHBr3 and KOH in a mixture of an inert solvent and water. Further an ester of compound (I) wherein R1 is H and R2 is 2-Cl is reacted with 4,5,6,7-tetrahydrothieno[3,2-c]pyridine to produce a compound of formula III: IMAGE which is useful as a medicament.