METHOD FOR THE BETECTION OF PREGNANCY DISORDERS USING A RADIOACTIVE IODINE-LABELLED ANTIGENREPRESENTED BY THE PROTEIN PP13

• 1. 用于孕早期预测妊娠期糖尿病的生物标记物、方法和预警模型 [P] . 中国专利： CN114034781A . 2022-02-11
• 2. 蛋白质标记用化合物、蛋白质标记用试剂盒以及蛋白质定点标记方法 [P] . 中国专利： CN113121384A . 2021-07-16
• 3. METHOD FOR THE DETECTION OF PREGNANCY DISORDERS USING A RADIOACTIVE IODINE-LABELLED ANTIGEN REPRESENTED BY THE PROTEIN PP13 [P] . IL78237A . 1991-06-30

  机译： 用蛋白质PP13代表的放射性碘标记抗原检测妊娠疾病的方法

• 4. RADIOACTIVE IODINE-LABELLED LAROTRECTINIB COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF [P] . 世界知识产权组织专利： WO2020119206A1 . 2020-06-18

  机译： 放射性碘标记的LAROTRECTINIB化合物及其制备方法和用途

• 5. IODINE-LABELLED RADIOACTIVE ESTRATRIENE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE IN RADIOIMMUNO ASSAYS AND IN THE PREPARATION OF ANTIGENS, AND ANTIGENS SO OBTAINED [P] . 德国专利： DE3367599D1 . 1987-01-02

  机译： 碘标记的放射性雌激素衍生物，制备方法和中间体，其在放射免疫分析中的使用以及在抗原的制备中以及所获得的抗氧化剂

• 1. Pregnancy-associated glycoproteins as a potential marker for diagnosis of earlypregnancy in goats: A scoping reviewing [J] . Nandini Sharma, Shiva Pratap Singh, Alok Bharadwaj, 亚太生殖杂志(英文版) . 2020,第006期
• 2. Combination of preparative and analytical ultracentrifugation methods for the investigation of low-density lipoprotein aliquots to prepare radioactive-labelled lipoproteins [C] . Zoltan Bozoky, Lajos Fulop, Gyozo Janoki Symposium on Analytical Ultracentrifugation . 2002
• 3. Application of bovine rapid pregnancy test kit of the early pregnancy diagnosis in ewes in comparison with progesterone and pregnancy-specific protein B assays. [D] . Chen, Wei. 2010
• 4. Analysis of Proteinuria Estimation Methods in Hypertensive Disorders of Pregnancy [O] . Hanumant V. Nipanal, Dilip Kumar Maurrya, S. Susmitha, 2018
• 5. The role of the carbohydrate recognition domain of placental protein 13 (PP13) in pregnancy evaluated with recombinant PP13 and the DelT221 PP13 variant. [O] . Marei Sammar, Shahar Nisamblatt, Ron Gonen, 2014

• 1. Effects of a Periodic Decay Rate on the Statistics of Radioactive Decay: New Methods to Search for Violations of the Law of Radioactive Change [J] . M. P. Silverman . 现代物理（英文） . 2015,第11期
• 2. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004） （P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期
• 3. GC-MS STUDY ON DIURETICS IN URINE Ⅰ.BETECTION METHOD USING METHYLATION [J] . Ya wei LI Jun LI Shao Tang ZHU Tong Hui ZHOU Institute of Materia MedicaChinese Academy of Medical Sciences Beijing 100050China . 中国化学快报：英文版 . 1990,第3期
• 4. C-type lectins and human epithelial membrane protein1:Are they new proteins in keratin disorders? [J] . Nilufer Karadeniz ,Thomas Liehr ,Kristin Mrasek . 遗传学期刊（英文） . 2013,第4期
• 5. Ⅱ型糖尿病与妊娠期糖尿病的蛋白质组学研究 [C] . 张雪晴 . 上海市病理专科分会2010年年会 . 2010
• 6. 新型断裂蛋白质内含子介导的蛋白质内部位点特异性标记 [A] . 张露 . 2018