A reliable and sensitive method is developed for the detection of commondiuretics in human urine. diuretics along with probenecid are methylated and subjectedto GC-MS analysis.Both chromatographic and mass spectrometric data are obtained inselected ion monitoring and full scanning modes.The average detection limit is 0.1-1.0ag/mi urine.This method is suitable to large-scale and routine screening orconfirmation of diuretics in doping control.
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