3,3-DISUBSTITUTED INDOLINES,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

The present Invention relates to a process for the preparation of indolinas 3.3 - disustituidas, in which p is 0 OR 1; Z is 0 or s; R is alkyl of C1 - C3 - C8 C10, cycloalkyl, 1 - piridilo,Piridilo 3 -, 4 - piridilo, or an Aromatic Ring substituents with V and W and V, W, X and y, are independently h, alkyl, Halo, C1 - C3, OR1, NO2 or CN, CF3, nr1r2; R1 and R2 are independently,H alkyl of C1 - C3 H and H independently;Heterocyclic Aromatic rings are of 6 members that contain at least one nitrogen Atom with the Ring optionally replaced with a substitutionary selected from GrupOr alkyl of C1 - C3, Halo, or nr1r2 OR1, or a pharmaceutically acceptable acid Addition Salt or n-oxide thereof, characterized in that it comprises: (a) contacting a oxindole.