PHENALKYLETHYLENEDIAMINE AND AMINOMETHYLTETRA HYDROISOQUINOLINE DERIVATIVES, PLATINUM (II) AND (IV) COMPLEXES, METHODS OF PREPARATION AND PHARMACEUTICAL COMPOSITIONS

摘要

Antitumor acting platinum(II or IV) complexes of the general formula IMAGE where B represents a phenyl-C1-C4-alkyl radical which is optionally substituted in the phenyl nucleus by the radical R1 and R1 is hydrogen, halogen, trihalogen methyl, C1-C6-alkyl, hydroxy, C1-C6-alkoxy or C2-C6-alkanoyloxy or where B together with the structural part H2N-CR2forms a tetrahydroisoquinoline radical, if B contains benzyl and R2 hydrogen and the benzyl radical in the 2-position contains the CH2-radical or where B together with the structural part -CR2 represents a tetrahydronaphthyl radical in which one CH2 group is optionally replaced by oxygen, or where B together with the structural part -CR2 represents a decahydronaphthyl radical or an indanyl radical; R2 represents hydrogen, C1-C6-alkyl, phenyl or phenyl-C1-C4-alkyl, it also being possible for the phenyl ring of this group R2 to be substituted by hydroxy, C1-C4-alkoxy, C1-C4-alkyl, C2-C6 -alkanoyloxy or halogen; the radicals R3 and R4 are the same or different and represent hydrogen, C1-C12-alkyl, C3-C8-cycloalkyl and X stands for the equivalent of a physiologically acceptable anion or X can also be a water molecule, where in the latter case the missing negative charge is saturated by a corresponding physiologically acceptable acid anion, where in the case of platinum(II) complexes, two of the groups X are absent.