METHOD OF RELIEVING NAUSEA AND EMESIS BY ADMINISTERING NOROXYMORPHONE DERIVATIVES; MIXTURE OF NOROXYMORPHONE DERIVATIVES AND A NARCOTIC ANALGESIC

摘要

QUATERNARY DERIVATIVES OF NOROXYMORPHONE WHICH RELIEVE NAUSEA AND EMESIS Quaternary derivatives of noroxymorphone are used to prevent or relieve nausea and emesis associated with the use of narcotic analgesics without interfering with the analgesic activity of the drugs. A particularly preferred compound is methylnaltrexone. The compound is administered in a concentration between 0.05 mg/kg and 1.0 mg/kg prior to or concurrently with the administration of the narcotic analgesic.