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PHARMACEUTICAL COMPOSITION FOR MODULATING REPRODUCTIVE PHYSIOLOGY IN MAMMALS COMPRISING HUMAN RELAXIN AND BUFFER
PHARMACEUTICAL COMPOSITION FOR MODULATING REPRODUCTIVE PHYSIOLOGY IN MAMMALS COMPRISING HUMAN RELAXIN AND BUFFER
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机译:包含人类松弛素和缓冲区的哺乳动物中调节生殖生理的药物成分
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摘要
A pharmaceutical composition is provided wherein human relaxin is formulated at an acidic pH of about 4 to less than about 7. The composition, useful for effecting parturition and inhibiting premature delivery, includes a buffer capable of maintaining the pH of the composition within a desired range, and may also include an agent to make the composition isotonic, and a stabilizing agent, if necessary. A specific example is human relaxin formulated in a citrate buffer, pH about 5.0, in the presence of sodium chloride, at an ionic strength of about 0.15 mu .
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