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DISINTEGRATABLE TABLET CONTAINING GEMFIBROZIL IN TWO GRANULATION FORMS TO PROVIDE BOTH IMMEDIATE AND SUSTAINED RELEASE
DISINTEGRATABLE TABLET CONTAINING GEMFIBROZIL IN TWO GRANULATION FORMS TO PROVIDE BOTH IMMEDIATE AND SUSTAINED RELEASE
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机译:在两种制粒形式中均含有吉非替尼的不可降解片剂,可即刻提供和持续释放
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摘要
A disintegratable formulation of gemfibrozil providing both immediate and sustained release and comprises a tablet compressed from a mixture of a first and second granulation, and a disintegration excipient operable to effect partial or complete disintegration in the stomach. The first granulation comprises finely divided particles of pure gemfibrozil granulated with at least one cellulose derivative and the second granulation comprises finely divided particles of pure gemfibrozil granulated with a pharmaceutically acceptable water soluble or insoluble polymer which are then uniformly coated with a pharmaceutically acceptable (meth)acrylate copolymer prior to admixture with the first granulation. The first and second granulations are present in the final composition in a ratio of from about 10:1 to about 1:10.
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