pharmaceutical composition innehaallande 4 - aroylimidazol - 2 - regions with antihypertensive, antithrombotic effect and kardioton

摘要

A compound for the alleviation of hypotension or the treatment of cardiac failure, having the formula IMAGE wherein R is hydrogen, C1-4 alkyl, (C1-4 alkyl) carbonyl or benzoyl; R1 is hydrogen or C1-4 alkyl; and Ar is 2-furyl; 2-thienyl; phenyl; phenyl monosubstituted by halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, trifluoromethyl, -SO2N(R2)2, NR3R4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkylpiperazino in which R2, R3 and R4 are independently selected from hydrogen and C1-4 alkyl; disubstituted phenyl in which one substituent is at the para position and the substituents are independently selected from halogen, hydroxy, C1-4 alkyl and C1-4 alkoxy; or 3,4-methylenedioxy- phenyl in which the methylene group is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof. Many compounds of formula I are novel.