THYMIDINE KINASE DELETION MUTANTS OF BOVINE HERPESVIRUS-1, VACCINES AGAINST INFECTIOUS BOVINE RHINOTRACHEITIS CONTAINING SAME AND METHODS FOR THE PRODUCTION AND USE OF SAME

摘要

THYMIDINE KINASE DELETION MUTANTSOF BOVINE HERPESVIRUS-1, VACCINES AGAINSTINFECTIOUS BOVINE RHINOTRACHEITIS CONTAINING SAMEAND METHODS FOR THE PRODUCTION AND USE OF SAMEABSTRACT OF THE DISCLOSUREBovine herpesvirus type 1 (infectious bovinerhinotracheitis virus) mutants which fail to produceany functional thymidine kinase as a result of adeletion in the thymidine kinase gene. The deletionin the thymidine kinase gene attenuates the viruses sothat they can be used as an active agent in a modifiedlive-virus vaccine against infectious bovine rhino-tracheitis. This invention also relates to methodsfor the production and use of the same.