PROCESS FOR SOLUBILIZATION, PURIFICATION AND CHARACTERIZATION OFPROTEIN FROM INSOLUBLE PROTEIN AGGREGATES OR COMPLEXES AND COMPOSITIONS OF MATTER THEREFROM

摘要

29,918TITLE: PROCESS FOR SOLUBILIZATION,PURIFICATION AND CHARACTERIZATION OFPROTEIN FROM INSOLUBLE PROTEIN AGGRE-GATES OR COMPLEXES AND COMPOSITIONSOF MATTER THEREFROMABSTRACT OF THE DISCLOSUREThis invention discloses a novel process for thesolubilization, purification and characterization of a pro-tein or proteins from insoluble protein aggregates or com-plexes. The novel process comprises the use of a dissociatingstep gradient which can be followed by further purificationand concentration. Also disclosed are compositions of matterand vaccines comprising one or more proteins purified ac-cording to the novel process of this invention.