ENHANCED GROWTH AND EXPRESSION OF HETEROLOGOUS PROTEINS IN RECOMBINANT HOSTS CONTAINING MUTATIONS IN CELL WALL AND/OR PLASMA MEMBRANE BIOSYNTHESIS

摘要

10/FSC7 17894 TITLE OF THE INVENTION ENHANCED GROWTH AND EXPRESSION OF HETEROLOGOUS PROTEINS IN RECOMBINANT HOSTS CONTAINING MUTATIONS IN CELL WALL AND/OR PLASMA MEMBRANE BIOSYNTHESIS A fermentation process as well as a medium for producing recombinant proteins in a host strain containing the desired mutation in cell wall and/or plasma membrane biosynthesis (e.g. mnn9) is disclosed. An example of such a strain is described in Merck's pending application Serial No. 202,764 filed June 3, 1988.