ENANTIOSELECTIVE, ENZYMATIC SYNTHESIS OF S(-) AND R(+)ESTERS OF 4-HYDROXY-CYCLOPENTENE-1-ONE AND ITS 2'-2'-DIMETHYLPROPANE-1,3'-DIOL-KETAL

摘要

2066689 9104337 PCTABS00003 The S(-) and R(+) esters of 4-hydroxy-cyclopentene-1-one and its 2',2'-dimethylpropane 1',3'-diol-ketal are produced by direct, enantioselective, enzymatic synthesis by reacting the corresponding 4-hydroxy compounds with an ester as acyl donor in the presence of an enzyme. The esters obtained are valuable intermediate products for stereospecific synthesis, in particular for the stereoselective synthesis of chemical compounds, in particular stable, storable, chiral prostaglandin derivatives, especially storable chiral prostaglandinsynthone.