HEPARIN-PRODUCING MURINE MASTOCYTOMA CELL LINES

摘要

Cell lines which can be grown continuously in culture and which provide glycosaminoglycan (GAG) compositions with high antiproliferative activity with respect to smooth muscle cells are disclosed. These cell lines permit the production of large amounts of antiproliferative GAGs which also lack antithrombin-binding activity. In addition, methods to obtain mutant cell lines which produce GAG compositions with desired activity spectra are disclosed.