THE EFFECT OF TRANSGLUTAMINASE INHIBITION ON MICROFILARIAE DEVELOPMENT AND MACROFILARIAE VIABILITY

摘要

A method is described for inhibiting maturation and production of microfilariae in adult filarial nematodes. Inhibition of transglutaminase or transglutaminase mediated reactions utilizing a transglutaminase inhibitor to block the maturation and production of microfilaria by the adult organism, as well as kill the adult filarial organism. Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor prove the described filaricidal effect of the adult organism existing independent of a host or existing within a host organism.