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THE EFFECT OF TRANSGLUTAMINASE INHIBITION ON MICROFILARIAE DEVELOPMENT AND MACROFILARIAE VIABILITY
THE EFFECT OF TRANSGLUTAMINASE INHIBITION ON MICROFILARIAE DEVELOPMENT AND MACROFILARIAE VIABILITY
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机译:谷氨酰胺转移酶抑制对微丝虫生长和大丝虫活力的影响
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摘要
A method is described for blocking maturation and production of microfilariae in adult filarial nematodes utilizing a transglutaminase inhibitor, such as monodansyl cadaverine (MDC). Experiments applying this method to several Brugia filarial infections, including Brugia malayi, were successful. Higher concentration of transglutaminase inhibitor proved to be filariacidal.
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