2-Amino purines substituted in positions 6 and 9, their use, medicaments containing these purines and processes for their preparation

摘要

Compounds of the formula 1 IMAGE in which R1 is H, halogen, OH, SH, azido, NH2 or Z-R5, where Z denotes O, S, SO, SO2 or NH and R5 denotes an acyclic aliphatic hydrocarbon radical having 1 to 6 C atoms, which a) is unsubstituted or b) is modified by at least one of the features that it contains an alkoxy group having 1 to 3 C atoms or a double bond or is at least partially fluorinated, or denotes cycloalkyl having 3 to 6 C atoms or phenylalkyl which is bonded directly to Z or via an alkylene group of 1 to 3 C atoms, or phenyl, where the phenyl ring can in each case be substituted at most twice, preferably at most once, by a substituent from the group halogen, trifluoromethyl, alkoxy and alkylthio each having 1 to 3 C atoms, R2 is H or has the meaning of R5 or is an acyl group CO-R6, where R6 is alkyl having 1 to 6 C atoms, benzyl or phenyl, R3 denotes halogen, azido, unsubstituted amino or the radical Y-R4, where R4 has the same meaning as R5 and Y, like X, denotes O, S, SO or SO2 and X and Y can be identical or different, where those compounds are excepted in which, at the same time, R1 is OH or SH, R2 is H, R3 is Y-R4, X is O or S, Y is O and R4 is alkyl having 1 to 4 C atoms or in which, at the same time, R1 is OH or NH2, R2 is benzyl, R3 is Y-R4 where Y = O and R4 = benzyl and X is O, are used for the treatment of diseases caused by viruses.