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Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections
Phospholipid particles encapsulating polyene antibiotics for the treatment of systemic fungal infections
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机译:封装多烯抗生素的磷脂颗粒用于治疗系统性真菌感染
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摘要
Formulations consisting of phospholipid small unilamellar particles encapsulating polyene antifungal antibiotics and methods for using such compositions to treat systemic fungal infections are described. In a preferred embodiment, the particles are in the form of vesicles which comprise a polyene antifungal antibiotic, preferably amphotericin B and/or nystatin, egg phosphatidylcholine and cholesterol, preferably in the molar ratio of about .2 (AMB):2(PL): 1(CHOL). These vesicles may also have an amine modified surface. The vesicles are suspended in a low ionic strength saccharide/tris solution at a pH of from about 6.0 to about 8.0 and may be administered to deliver the antifungal antibiotic to treat systemic fungal infections.
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