wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R₁ and R₂ are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof are active as antiemetics. Two of the preferred compounds are fenfluramine and norfenfluramine."/>
Anti-emetic serotonin depleting agents
Compounds of the formula: wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R₁ and R₂ are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof are active as antiemetics. Two of the preferred compounds are fenfluramine and norfenfluramine.
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机译：下式的化合物： <图像文件=“ IMGA0001.GIF” he =“ 27” imgContent =“ chem” imgFormat =“ GIF” wi =“ 65” /> 其中，R选自氢，低级烷基，三氟甲基，羧基或低级烷氧羰基; R 1和R 2是氢或低级烷基; Z为三氟甲基或卤素;旋光异构体及其药学上可接受的盐具有止吐作用。两种优选的化合物是芬氟拉明和去甲氟拉明。
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