Ruthenium complexes containing a DNA or RNA sequence

摘要

There are ruthenium complex compounds comprising a DNA or RNA sequence which covalently, preferably via a spacer, to a ruthenium complex of the general formula I Ru²⁺L₁L₂L₃ is attached will be described. The radicals L₁ and L₂ are the same or different, and represent charge transfer units. L₃ is also a charge transfer unit, which is substituted with a group AX. Here, A is an alkylene group which may be sub stituiert optionally substituted by -SO₂-NH-, -S-, -0-, -COO- or -CO-NH- and X is an aldehyde, carboxy, amino, hydroxy -, thiocyanato, halogen or a phosphite or a phosphate group or a modified phosphate group, for example, means a phosphonate or thiophosphonate or otherwise suitable function. The RNA or DNA sequence is linked either in unmodified form or in unmodified form directly or via a spacer group by reaction with the ruthenium complex is covalently.; The charge transfer units L₁, L₂ and L₃ may be same or different and bipyridyl, bathophenanthroline or Banzbatho represent phenantrolin that Ki be optionally substituted NEN.