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Avoidance of human anti-mouse antibody interference in in vitro diagnostic testing
Avoidance of human anti-mouse antibody interference in in vitro diagnostic testing
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机译:在体外诊断测试中避免人抗小鼠抗体的干扰
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摘要
The present invention enables the performance of immunoassays which use mouse monoclonal antibody assay reagents but in which human anti-mouse antibody-induced interference is substantially avoided without the need for cumbersome sample pretreatment steps and without denaturing the analyte epitope(s) necessary to the binding reactions of the immunoassay. The present invention also enables the determination of the presence or amount of interfering antibodies in the test sample. For example, bridging assays for the detection of the presence or amount of human anti-mouse antibodies in a test sample can be configured to determine anti-allotype, anti-idiotype antibodies and/or anti-isotype antibodies. Homogeneous and heterogenous assay methods and sandwich and competitive assay formats are described.
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