PYRUVATE-KINASE-ISOENZYME-TYPE-M2 (TUMOUR M2-PK) SPECIFIC ANTIBODIES, PROCESS FOR PRODUCING THEM AND USE

摘要

Pyruvate kinase (ATP: pyruvate 2-O-phosphotransferase, EC 2.7.1.40) -isoenzyme type M2 (M2-PK tumor) can be determined qualitatively, quantitatively and locally using antibodies found in the blood , plasma, tissue cultures, tissue sections, as well as in the animal or human body. The corresponding antisera are obtained by using, as an immunogen, an ultrapure pyruvate kinase-isoenzyme of the M2 (M2-PK tumor) type, or fragments thereof. Preferably, antisera with monoclonal antibodies are used. These antibodies can be used to diagnose cancer and determine cell malignancy using ELISA analysis systems, to locate tumors in the body, and to treat cancer.