prostacyclinanalog, this active component containing the blutumlauf corrective means and against magengeschwuere acting means.

摘要

A prostacyclin analogue having the formula: IMAGE (I) wherein R1 is -CO2R5 (wherein R5 is a hydrogen atom, a straight chain or branched alkyl group having from 1 to 12 carbon atoms, an aralkyl group having from 7 to 12 carbon atoms, a cycloalkyl group having from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group having from 1 to 4 carbon atoms, a substituted or unsubstituted phenyl group, or one equivalent of a cation), or -CONR6R7 (wherein each of R6 and R7 is a hydrogen atom or an alkyl group having from 1 to 10 carbon atoms, or R6 and R7 together with the adjacent nitrogen atom, form a 5- or 6-membered substituted or unsubstituted hetero ring which may contain a hetero atom other than said nitrogen atom); A is -CH2CH2CH2-, CH2-O-CH2CH2-, -CH2CH2CH2CH2-, -CH2CH2-O-CH2- or -CH=CHCH2CH 2-; B is trans -CH=CH- or -C 3BOND C-; R2 is a straight chain or branched alkyl group having from 3 to 10 carbon atoms, a cycloalkyl group having from 4 to 7 carbon atoms and unsubstituted or substituted by at least one alkyl group having from 1 to 4 carbon atoms, a straight chain or branched alkenyl group having from 3 to 12 carbon atoms, a straight chain or branched alkynyl group having from 3 to 8 carbon atoms, or an alkyl group having from 1 to 3 carbon atoms substituted by a substituted or unsubstituted phenyl or phenoxy group, by an alkoxy group having from 1 to 6 carbon atoms or by a cycloalkyl group having from 5 to 8 carbon atoms; R3 is a hydrogen atom, a methyl group or a vinyl group; and R4 is a hydrogen atom, an acyl group having from 1 to 7 carbon atoms, a tri-C1-C7 hydrocarbon-silyl group or a group capable of forming an acetal bond together with the oxygen atom of a hydroxyl group; provided that the double bond in a substituent for A is E or Z, or a mixture thereof; the asymmetric center in a substituent for R2 assumes a R-conformation or a S-conformation, or a mixture thereof; and the bonds shown by dotted lines at the 2-3 and 3-4 positions mean that either one of them is a double bond.