Monoclonal antibodies antiphospholipase a2 of venoms of segments of the families of elapids and hydrophides, 1995 of preparation and their use for the antivenom

摘要

The present invention relates to monoclonal antibodies antiphospholipase a2 of venoms of segments of the families of elapidae and hydrophidés, to processes for their preparation and to their use for the screening antivenom. / p & & p & the antibodies antiphospholipase a2 (anti - pla2) of venoms of segments, according to the invention are constituted by the monoclonal antibodies polyspecific, that is - to - say capable of recognizing not only the pla2 used for preparing them, but also at least one other pla2 toxic venoms of segments of the families of elapidae and hydrophidés, in that the said antibodies are of the igg1, k, in that they have a high affinity for the notexin, expressed by their dissociation constant kd, between 1,4x10 * * * * - 9m and 15,8x10 * * * * - 9m. / p & & p & antigenic fragments of a plurality of pla2 of venoms of segments of the families of elapidae and hydrophidés recognized by the monoclonal antibodies polyspecific. / p & & p & application to the screening antivenom.