Process for the preparation of N-(2-amino-3,5-dibromobenzyl)-trans-amino-cyclohexanol

摘要

The compound of formula I IMAGE and pharmaceutically acceptable acid-addition salts thereof are prepared by reacting the 4-trans- (N-isopropylideneamino)-cyclohexanol of formula II IMAGE with 2-amino-3,5-dibromo-benzaldehyde of formula IV IMAGE optionally transforming the 2-amino-3,5-dibromobenzylidene-4-(trans-amino)-cyclohexanol of formula V IMAGE thus obtained into the acid-addition salt of formula VI IMAGE with the aid of a mineral acid, then reducing the same and isolating the acid-addition salt of N-(2-amino-3,5-dibromobenzyl)-trans-4-amino-cyclohexanol of formula I.