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MYOCARDIAL SYMPATHETIC NERVE-IMAGING AGENT

机译:心肌交感神经成像剂

摘要

PURPOSE:To provide the title imaging agent specifically accumulating on the myonurocytes from an early stage of its administration and capable of giving clear myocardial tomogram, containing, as the chief component, m-iodobenzyl guanidine labeled with radioactive iodine of high specific activity. CONSTITUTION:The objective imaging agent containing, as the chief component, m-iodobenzyl guanidine (MIBG) labeled with radioactive iodine = 370 (pref. =1000)MBq/mg in specific activity. Valuable information for the early stage detection of and therapeutic policies for various kinds of cardiopathy(myocardial infarction, stenocardia, and myocardiopathy) can be obtained by administration of said radioactive iodine-labeled MIBG at a level of = 10 (pref. = 5) mug/kg body weight and by making an imaging and analysis according to the conventional procedure.
机译:目的:提供一种标题成像剂,其从给药初期就专门积聚在肌红细胞上,并且能够给出清晰的心肌X线照片,其主要成分是间碘碘苄基胍,所述间碘苄基胍标记有高比活度的放射性碘。组成:该物镜成像剂主要成分为间碘碘苄基胍(MIBG),其放射性标记为比活度≥370(优选≥1000)MBq / mg。可以通过将放射性碘标记的MIBG的含量≤10(优选<= 5)进行给药,从而获得各种心脏病(心肌梗塞,狭窄性心律失常和心肌病)的早期检测和治疗策略的重要信息。杯/ kg体重,并按照常规程序进行成像和分析。

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