IMMUNOLOGICAL FUNCTION PROMOTING AGENT FOR ORAL AND TRANSCUTANEOUS ADMINISTRATION AND IMMUNOLOGICAL FUNCTION PROMOTING AGENT FOR ANIMAL FOR ORAL AND TRANSCUTANEOUS ADMINISTRATION

摘要

PURPOSE:To provide an immunological function promoting agent for oral and transcutaneous administration, containing Bordetella pertussis LPS, having high immunological function activation capability and high chemotherapeutic index and producible at a low cost. CONSTITUTION:The objective agent contains Bordetella pertussis LPS preferably having a molecular weight of 6000+ or -1000 and 9000+ or -1000 (determined by SDS electrophoresis) and containing 5 P atoms, 16+ or -2 hexosamine groups, 5 fatty acid groups and 2+ or -1 KDO based on 8,000 molecular weight. The immunological function is e.g. macrophage-activation property, especially endogenous TNF- production promoting property. The immunological function promoting activity can be further improved by the combined use of an agent for suppressing the production of prostaglandin (e.g. indomethacin).