DIMETHYLANILINE DERIVATIVE, PREPARATION THEREOF AND CANCER CELL DIFFERENTIATION-INDUCING EXAMINATION REAGENT AND CANCER DRUG CONTAINING THE SAME AS ACTIVE INGREDIENT

摘要

NEW MATERIAL:A dimethylaniline derivative of formula I. USE:Useful as a cell differentiation-inducing examination reagent and a carcinogenic agent. Since the compound exhibits a strong cell differentiation-inducing activity in a low concentration and has a low cellular toxicity, the compound can be utilized for the clarification of cellular differentiation mechanism and carcinogenesis mechanism. The compound can be readily manufactured in large amounts. Orally or parenterally administrable. PREPARATION:A grignard reagent of formula II is reacted with glutaric anhydride in a ratio of 1:1-1:10, preferably 1:1-1:2, and the prepared carboxylic acid is esterified into methyl ester thereof. The prepared ester of formula III is reacted with hydroxylamine in the presence of a based to prepare the compound of formula I.