USE OF 2, 3-DISUBSTITUTED 1-AZOLYL-PROPANE AS GROWTH INHIBITOR AGAINST DIMORPHIC YEAST CELL IN PATHOGENIC PERIOD

摘要

PURPOSE: To obtain a medicine preparation suitable for alleviating and preventing systemic mycosis, especially systemic mycosis caused by Candida albicans, toxicologically slightly harmful, comprising a 2,3-disubstituted 1-azolyl- propane as an active ingredient. CONSTITUTION: This medicine comprises a compound of formula I [A is CH or N; X is NR1 R2 , O-phenyl, O-benzyl, S-phenyl, O-N=CR3 R4 (R1 is an alkyl, an alkenyl, phenyl, a heteroaryl, naphthyl, etc.; R2 is H or R1 ; R3 is phenyl, biphenyl, benzyl, an alkyl, etc.; R4 is H, an alkyl, an alkenyl, phenyl, benzyl, etc.); Y is OH, SH, F, CI, Br, Z-R5 , OC(O)R5 , OC(S)R5 , etc., (Z is O, S, SO or SO2 ; R5 is an alkyl, an alkenyl, a cycloalkyl, phenyl, a heteroaryl, naphthyl, etc.)] such as a compound of formula II as an active ingredient.