INDUCEMENT OF PROTECTIVE ACTION AGAINST VIRUS INFECTION BY SYNERGISM BETWEEN PEPTIDES COR- RESPONDING TO VIRUS ENVELOPE GLYCOPROTEIN AND NEUTRAL EPITOPE OF ITS GLYCOPROTEIN

摘要

PURPOSE: To impart persistent immunity against virus to a host by administering a viral envelope glycoprotein and a peptide derived from an amino acid sequence of the envelope glycoprotein and containing neutralized epitope to the host, and enhancing the induction of a neutralizing antibody. CONSTITUTION: At least one viral envelope glycoprotein, preferably the whole molecule obtained before scission to be expected (e.g. gp 160 is preferable than gp 120 in a case of HIV-1) and a peptide derived from an amino acid sequence of the envelope glycoprotein and containing at least one neutralized epitope are administered to a host. Onset preventive vaccination is preferably performed by the injection of the envelope glycoprotein, and protective immunity is preferably enhanced by the injection of immunogenic peptide corresponding to the neutralized epitope.