The compound obtained by this method is used in medicine for the preparation of a broad spectrum of parenteral antibiotics. The method is technically simplified and the product is obtained at higher yields, with respect to the raw materials. The method involves adding a suspension of diketopiperazine carbonyl chloride and triethyl amine hydrochloride in anhydrous organic solvent to p-hydroxyphenyl glycine after silylating the latter in a medium of the same solvent. The resulting 2-[(N-ethyl-2,3-dioxo-piperazinyl)carboxamido]-2-(p- hydroxyphenyl)-acetic acid is isolated and after activation with chlorine agents, is reacted with a sylilic derivative of 7-amino-3-/-5-(1-methyl)-1,2,3,4-tetrazolyl) thiomethyl/-cephalosporanic acid in a medium of dimethyl acetamide.
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