首页>
外国专利>
PROCESS OF THE PREPARATION IN A SINGLE VESSEL OF HYDROCHLORIDE OF ALPHA-L-ASPARAGYL-L-PHENYLALANINE METHYL ESTER
PROCESS OF THE PREPARATION IN A SINGLE VESSEL OF HYDROCHLORIDE OF ALPHA-L-ASPARAGYL-L-PHENYLALANINE METHYL ESTER
展开▼
机译:α-L-天冬酰胺基-L-苯丙氨酸甲酯的氢氯化物在单个容器中的制备工艺
展开▼
页面导航
摘要
著录项
相似文献
摘要
One-pot prodn. of alpha-L-aspartyl-L-phenylalanine methyl ester HCL (alpha-APM.HCL) comprises; (a) formylating L-aspartic acid in a first reaction mixt. of HCOOH, Ac2O, and a secondary alcohol to yield N-formyl-L-aspartic anhydride (FAA); (b) coupling in situ with L-phenylalanine at a temp. to yield alpha-and beta-N-formyl-L-aspartyl-L-phenylalanine isomers (FAP); (c) deformylating the isomers by addn. of HCL; (d) removing residual HCOOH and Ac2O from the reaction mixt.; (e) esterifying the deformylated isomers by addn. of MeOH to the reaction mixt., to yield a mixt. of alpha- and beta-APM, HCl, of which the alpha isomer ppts.; and (f) isolating the alpha-APM.HCl.
展开▼