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PROCESS FROM EXTRACTING MATERIAL HAVING ANTICOAGULANT ACTIVITY FROM HAEMENTERIA GHILIANII LEECH AND FOR PURIFYING SAME
PROCESS FROM EXTRACTING MATERIAL HAVING ANTICOAGULANT ACTIVITY FROM HAEMENTERIA GHILIANII LEECH AND FOR PURIFYING SAME
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机译:从姬氏黑单胞菌水CH中提取具有抗凝血活性的物质并进行纯化的方法
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摘要
Applicant has isolated a Factor Xa inhibiting substance from the salivary gland extract of the leech H. ghilianii. The extract is subjected to separation using both DEAE-cellulose and heparin-agarose chromatography resins eluting with an increasing salt gradient. The extract is subjected to affinity chromatography using Factor Xa bound to an Affi-Gel-15 resin eluting with HEPES containing benzamidine. Reverse phase chromatography yields several purified peptides or proteins having Factor Xa inhibiting activity. The properties and clinical compositions of these FXa inhibitors are described.
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