METHOD FOR RADIOIMMUNOLOGICAL DETERMINATION OF 9ALPHA-11BETA-PGF2 CONTENT AND METHOD FOR PRODUCING RADIOLIGAND MARKED BY ISOTOPE OF IODINE-125 USED FOR SAID DETERMINATION

摘要

Radio-ligand of formula (I) 125I isotope tracer contg. 9alpha, 11 beta-PGF2-iodo -tyrosine-methyl-ester of formula (I), is prepd. from 9alpha 11 beta-PGF2-tyrosine -methyl-ester and Na 125I under favourable reaction condns. - The radio-ligand has exceptionally high specific activity and consequently the sensitivity of the detn. of the 9alpha, 11 beta-PGF2 content of sample specimens, based on an antigen-antibody reaction, is high i.e. few picogm/ml.