PROCESS FOR PRODUCING NEW 19-NORSTEROID DERIVATIVES CARRYING CARBON CHAIN COMPRISING AMIDO GROUP IN 11BETA POSITION AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME

摘要

The invention relates to the compounds: IMAGE either n = 1, K = oxygen, R17 = hydroxyl, IMAGE R'17 = hydrogen, ethynyl, RA = methyl, RA' = isopropyl, butyl, heptafluorobutyl, X = methylene, phenylene or phenyloxy, Y = -(CH2)7; -(CH2)8-; -(CH2)5-C IDENTICAL C-; -(CH2)q-O-CH2-, q = 5 to 7, and -(CH2)5-S-CH2-, or n = 1 or 2, K = oxygen or sulphur, R17 and R'17 = ketone or R17 = hydroxyl or acyloxy and R'17 = hydrogen, alkyl, alkenyl, alkynyl, X = methylene, arylene, CH2-O, arylenoxy or arylenethio, Y = a bond or aliphatic chain optionally interrupted by arylene, oxygen or sulphur, optionally oxidised, and optionally ending with arylene, Z = bond and if Y and Z = bond, X NOTEQUAL CH2 or CH2-O, RA or RA' = hydrogen, alkyl, heterocycle (5 or 6 members) optionally substituted with RA or RA' NOTEQUAL hydrogen, - or n = 2, or K = sulphur, or X = arylenethio, or RA and RA' = heterocycle substituted by aryl or aralkyl, their preparation, their application as medicinal products and pharmaceutical compositions containing them.