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PROCESS FOR CLONING FRAGMENT ENCODING THE SYNTHESIS OF TETRACYCLINE AND CHLOROTETRACYCLINE AND FOR EXPRESSING CLONED FRAGMENTS
PROCESS FOR CLONING FRAGMENT ENCODING THE SYNTHESIS OF TETRACYCLINE AND CHLOROTETRACYCLINE AND FOR EXPRESSING CLONED FRAGMENTS
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机译:克隆片段的过程,包括合成四环素和氯四环素以及表达克隆片段
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摘要
The present invention relates to the cloning, isolation and DNA (isolated fragment from Streptomyces aureofaciens) which directs the synthesis of tetracycline and chlortetracycline, in a heterologous host such as Streptomyces lividans. The claimed plasmids are isolated by screening a cosmid library, constructed in Escherichia coli, for the expression of tetracycline resistance in S. lividans.
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