GOLFOMYCIN DERIVATIVES: NOVEL FUSED RING CYCLODECADIYNE¹DERIVATIVES HAVING DNA-CLEAVING PROPERTIES AND ANTITUMOR¹ACTIVITY

摘要

5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods of making and using the same are also disclosed.