CARBOHYDRATE DERIVATIVES COMPRISING A TRISACCHARIDE UNIT,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

摘要

Carbohydrate derivatives comprising a trisaccharide unit having the general formula I CHEM in which R is alkyl, aryl, or aralkyl; Q is alkyl, aryl, aralkyl, or SO3-; A and B are independently selected from hydrogen, alkyl, aryl, aralkyl, or a carbohydrate group; and the charged moieties are compensated by counter-ions. The carbohydrate derivatives of this invention possess anti-thrombotic activity, and especially they have potent anti-Xa activity without activating thrombin via anti-thrombin-III (AT-III) and smooth muscle cell proliferation inhibiting activity.