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SUSTAINED RELEASE PHARMACEUTICAL PELLET COMPOSITION COMPRISING A CORE COATING MATERIAL SLIGHTLY SOLUBLE AT LOW PH ALLOWING LATER FASTER RELEASE
SUSTAINED RELEASE PHARMACEUTICAL PELLET COMPOSITION COMPRISING A CORE COATING MATERIAL SLIGHTLY SOLUBLE AT LOW PH ALLOWING LATER FASTER RELEASE
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机译:缓释药丸成分,包括核心涂料,在低pH下微溶,允许较早释放
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摘要
A sustained release pharmaceutical pellet composition suitable for treating pain-associated conditions in patients comprises a core element including at least one active ingredient of high solubility; and a core coating for the core element which is partially soluble at a highly acidic pH to provide a slow rate of release of active ingredient e.g a morphine compound, and wherein the active ingredient is available for absorption at a relatively constant faster rate in the intestine over an extended period of time, such that blood levels of active ingredient are maintained with the therapeutic range over an extended period of time.
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