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BIKUNIN (SUBUNIT OF INTER-ALPHA-TRYPSIN INHIBITOR) AND FRAGMENTS WITH INHIBITORY ACTIVITY
BIKUNIN (SUBUNIT OF INTER-ALPHA-TRYPSIN INHIBITOR) AND FRAGMENTS WITH INHIBITORY ACTIVITY
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机译:Bikunin(α-胰蛋白酶抑制剂的亚单位)和具有抑制活性的片段
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摘要
The invention comprises peptide variants based on the domains with inhibitory activity of human bicunin (i.e. the component with inhibitory activity of inter- alpha -trypsin inhibitor, or the acid-stable serum trypsin inhibitor, or the urinary trypsin inhibitor), methods for the preparation of these peptide variants with the aid of genetic engineering methods with microorganisms (bacteria, lower eukaryotes), and pharmaceutical compositions containing these peptide variants. The peptide variants are characterised by their ability to inhibit serine proteases, e.g. pancreatic and granulocytic elastase, cathepsin G or plasma kallikrein.
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