OPTICALLY ACTIVE ALKYL 2R-CHROMAN-2-CARBOXYLATES PREPARED BY PARTIAL HYDROLYSIS OF THE RACEMIC ESTER USING A MICROBIAL LIPASE; OPTICALLY ACTIVE 2R BENZYLCHROMAN DERIVATIVES

摘要

Optically active (C1-C3)alkyl 2R-chroman-2-carboxylates are prepared by partial hydrolysis of the corresponding racemic ester using a microbial lipase as catalyst. Said 2R-chromancarboxylate is converted via novel 2R-(hydroxymethyl)chroman, 2R-(trifluoromethylsulfonyloxymethyl)chroman and 2R-benzylchroman intermediates into 2R-benzylchroman-6-carbaldehyde, a compound of known utility in the manufacture of certain hypoglycemic agents.