An Optical Resolution of Racemic Organophosphorous Esters by Phosphotriesterase-Catalyzing Hydrolysis

摘要

We have shown that PTE chiral recognition is limited to organophos-phorous esters having the chiral center on the phosphorous atoms, which is attacked with nucleophile, not having the chiral center on the other atoms of the leaving group. Therefore, PTE can be utilized for the synthesis of their chiral organophosphorous esters.